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Transposable elements drive widespread expression of oncogenes in human cancers.

Nat Genet. 2019;

Jang HS,, Shah NM,, Du AY,, Dailey ZZ,, Pehrsson EC,, Godoy PM,, Zhang D,, Li D,, Xing X,, Kim S,, O'Donnell D,,, Gordon JI,,, Wang T,.

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Monoclonal Antibody Services	4196) and an anti-ACTB mouse monoclonal antibody (GenScript, A00702), respectively.... Reporting for specific materials, systems and methods Materials & experimental systems Methods n/a Involved in the study n/a Involved in the study Unique biological materials Antibodies Eukaryotic cell lines Palaeontology Animals and other organisms Human research participants ChIP-seq Flow cytometry MRI-based neuroimaging Antibodies Antibodies used LIN28B Antibody #4196 (Cell Signaling Technology, Cat #4196S, Lot #5) 1:1000 dilution Anti-ACTB Mouse Monoclonal Antibody (GenScript, Cat #A00702, Lot #15E000905) 1:5000 dilution of 0.	Get A Quote

摘要

Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1-3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a process termed onco-exaptation4. However, the prevalence and impact of TE onco-exaptation events across cancer types are poorly characterized. Here, we analyzed 7,769 tumors and 625 normal datasets from 15 cancer types, identifying 129 TE cryptic promoter-activation events involving 106 oncogenes across 3,864 tumors. Furthermore, we interrogated the AluJb-LIN28B candidate: the genetic deletion of the TE eliminated oncogene expression, while dynamic DNA methylation modulated promoter activity, illustratin... More